NIK-IN-3

SKU: orb3174373

Description

NIK-IN-3 is a potent, orally active inhibitor of NF-κB-inducing kinase (NIK) with an IC50 value of 5.2 nM. It effectively suppresses activation of the non-canonical NF-κB pathway and inhibits the secretion of pro-inflammatory cytokines, including TNF-α, IL-6, IL-1β, and the chemokine CXCL12. NIK-IN-3 demonstrates significant anti-inflammatory effects in LPS-induced sepsis and DSS-induced colitis mouse models. This compound is applicable in inflammation-related research, such as studies on colitis.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• Target: NF-κB,Interleukin,TNF,CXCR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NF-κB,Interleukin,TNF,CXCR