Nigranoic acid

SKU: orb3054237

Description

Nigranoic acid is a natural product,and inhibits HIV-1 reverse transcriptase.

Key Properties

• CAS Number: 39111-07-4
• MW: 470.68
• Purity: >98% (HPLC)
• Formula: C₃₀H₄₆O₄

Bioactivity

• In Vivo:
  Nigranoic acid has a strong protective effect on rat cerebral ischemia-reperfusion injury, and acts by downregulating nerve cell apoptosis by preventing the overactivation of PARP and AIF nuclear translocation. Nigranoic acid (1 mg/kg; i. g. ; 6 hours and 2 hours before brain ischemia) significantly decreases apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points. Animal model: Sprague–Dawley rats (200-300 g), ischemia–reperfusion model. Dosage: 1 mg/kg. Administration: Intragastric; 6 hours and 2 hours before brain ischemia. Result: Decreased apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only