Niflumic acid

SKU: orb1310379

Description

Niflumic acid

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 4394-00-7
• MW: 282.22
• Purity: 99.79%
• Formula: C₁₃H₉F₃N₂O₂
• SMILES: OC(=O)C1=CC=CN=C1NC1=CC=CC(=C1)C(F)(F)F
• Target: Chloride channel,Monocarboxylate transporter,UGT,Phospholipase,COX
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:60 mg/mL (212.6 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.09 mM)

Bioactivity

• Target IC50:
  COX-2:100 nM
• In Vivo:
  Niflumic acid suppresses calcium-activated currents o the basolateral membrane of rat pancreatic exocrine cells with an IC50 of 50 μM. It dose-dependently and reversibly activate the calcium-activated potassium (KCa) channels. Niflumic acid induces a spontaneous transient concentration dependent Inhibition of inward currents (STIC, calcium-activated chloride currents) amplitude. It inhibits calcium-activated chloride channels with a Ki of 17 mM. Additionally, Niflumic acid suppresses ICl(Ca) unde the permeabilizing effect of Ca2+ on oocytes through Ca2+ ionophore A23187, suggestin the Inhibition of ICl(Ca) results from Direct interaction with Cl- channels, not by disruption of Ca2+ entry through voltage-dependent Ca2+ channels. Niflumic acid attenuates norepinephrine and caffeine-induced inward currents (IO(Ca)) with an IC50 of 6.6 μM, which is less effective than that on spontaneous currents. It exhibits a voltage-dependent Inhibition o the amplitude of spontaneous transient currents (STIC), with IC50 Values of 1.1 μM at +50 mV and 2.3 μM at -50 mV. furthermore , Niflumic acid reduces airway hyperresponsiveness and eosinophilic infiltration, as well as inhibits IL-13 induced goblet cell hyperplasia. Followin the IL-13 challenge, Niflumic acid hamper the overexpression o the MUC5AC gene (a marker of goblet cell proliferation) and levels of chemokines in bronchoalveolar lavage fluid. It also represse the activation of JAK/STAT6, AK2, an the expression of chemokines in epithelial cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

PLA2, UGT, COX, Chloride channel protein ClC-Ka, Chloride channel, Chloride Channel, Chloridechannel, Cl? Channels, Niflumic acid, Nifluril, inhibit, Monocarboxylatetransporter, Monocarboxylate transporter, Forenol, Inhibitor, Landruma

Compound Identifiers

PubChem CID

4488