Nifekalant hydrochloride

SKU: orb1909602

Description

Nifekalant hydrochloride is a Class III antiarrhythmic agent that selectively blocks the IKr potassium channel with an IC50 of 10 µM. It is utilized in research to study ventricular tachyarrhythmias, employing both in vitro electrophysiology assays and in vivo animal models of arrhythmia.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 130656-51-8
• MW: 441.91
• Purity: 98.00%
• Formula: C₁₉H₂₈ClN₅O₅
• SMILES: Cl.Cn1c(NCCN(CCO)CCCc2ccc(cc2)[N+]([O-])=O)cc(=O)n(C)c1=O
• Target: Potassium Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.26 mM);DMSO:9 mg/mL (20.37 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antiarrhythmic, Inhibitor, IKr, inhibit, MS551, MS-551, MS 551, KcsA, Nifekalant, Nifekalant Hydrochloride, Nifekalant hydrochloride, Potassium Channel, potassium channel, PotassiumChannel, tachyarrhythmias, ventricular

Compound Identifiers

PubChem CID

122188