Nicotinic acid

SKU: orb1224536

Description

Niacin (Vitamin B3) is a water-soluble vitamin and is part of the vitamin B group. (In Vitro):Niacin (0-900 μM, 42 hours) significantly increases GSH levels and decreases ROS levels, and affects the expression of genes related to apoptosis and lipid metabolism.Niacin (0-40 μM, 24 hours) can inhibit cancer invasive activity at low dose but with no influence on proliferation.(In Vivo):Niacin (subcutaneous injection, 3-300 mg/kg, once) can induce vasodilation in a dose-dependent manner within minutes in male C57BL/6 mice.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 59-67-6
• MW: 123.11
• Purity: >98% (HPLC)
• Formula: C₆H₅NO₂
• SMILES: O=C(C1=CC=CN=C1)O
• Target: Vitamin
• Solubility: Water: 2 mg/mL (16.24 mM); DMSO: 25 mg/mL (203.07 mM)

Bioactivity

• In Vivo:
  Niacin (subcutaneous injection, 3-300 mg/kg, once) can induce vasodilation in a dose-dependent manner within minutes in male C57BL/6 mice. Animal model: Male C57BL/6 mice. Dosage: 3-300 mg/kg. Administration: Subcutaneous injection; once. Result: Induced vasodilation in a dose-dependent manner.
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• In Vitro:
  Niacin (0-900 μM, 42 hours) significantly increases GSH levels and decreases ROS levels, and affects the expression of genes related to apoptosis and lipid metabolism. Niacin (0-40 μM, 24 hours) can inhibit cancer invasive activity at low dose but with no influence on proliferation. RT-PCR Cell line: Cumulus cells and oocytes of prepubertal gilts. Concentration: 600 μM. Incubation time: 42 hours. Result: Up-regulated the relative expression of the anti-apoptotic gene BCL2 and lipid metabolism gene ACACA while down-regulated the pro-apoptotic gene BAX. Cell Proliferation Assay Cell line: Rat ascites hepatoma cell line of AH109A. Concentration: 0-40 μM. Incubation time: 24 hours. Result: Had no effect on the proliferation of AH109A cells but suppressed cell invasion from 2.5 μM to 40 μM.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Niacin | NSC 169454 | NSC-169454 | NSC169454

Quick Database Links

Gene Symbol

Vitamin