Nicotinamide riboside

SKU: orb1308786

Description

This small molecule research compound elevates cellular NAD+ levels, thereby activating sirtuins SIRT1 and SIRT3. It is widely used in metabolic research to study oxidative metabolism and has demonstrated protective effects against diet-induced metabolic dysfunction in both in vitro and in vivo models.

Research Area

Epigenetics & Chromatin, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 1341-23-7
• MW: 255.25
• Purity: 99.58% (May vary between batches)
• Formula: C₁₁H₁₅N₂O₅
• SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)[N+]=2C=C(C(N)=O)C=CC2
• Target: Endogenous Metabolite,Sirtuin
• Solubility: H2O:50 mg/mL (195.89 mM);DMSO:125 mg/mL (489.72 mM)

Bioactivity

• In Vivo:
  The natural vitamin Nicotinamide riboside (NR) could be used as a nutritional supplement to ameliorate metabolic and age-related disorders characterized by defective mitochondrial function.
• In Vitro:
  Nicotinamide riboside (NR) supplementation in mammalian cells and mouse tissues increases NAD(+) levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high-fat diet-induced metabolic abnormalities.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

abnormalities, Alzheimer's, dietary, COVID-19, Endogenous Metabolite, Inhibitor, inhibit, orally, Nicotinamide riboside, niacin, oxidative, NAD+, PARP, metabolic, metabolism, vitamin, supplements, SIRT3, SIRT1, Sirtuin

Compound Identifiers

PubChem CID

439924