Nicotinamide riboside

SKU: orb1219709

Description

Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities.Nicotinamide riboside (NR) supplementation in mammalian cells and mouse tissues increases NAD(+) levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high-fat diet-induced metabolic abnormalities.The natural vitamin Nicotinamide riboside (NR) could be used as a nutritional supplement to ameliorate metabolic and age-related disorders characterized by defective mitochondrial function.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1341-23-7
• MW: 255.25
• Purity: >98% (HPLC)
• Formula: C₁₁H₁₅N₂O₅
• SMILES: NC(=O)c1ccc[n+](c1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
• Target: Sirtuin

Bioactivity

• In Vivo:
  Chronic Nicotinamide riboside (p.o. ; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD+ content in a tissue-specific manner. Animal model: 10-week-old C57Bl/6J mice. Dosage: 400 mg/kg. Administration: p.o. ; daily; for 16 weeks. Result: Increased plasma and intracellular NAD+ content in a tissue-specific manner.
• In Vitro:
  Nicotinamide riboside (0.5 nM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2.Nicotinamide riboside increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1000 μM. Nicotinamide riboside boosts NAD to restore antiviral poly(ADP-ribose) polymerase (PARP) functions to support innate immunity for coronavirus (CoVs), a cause of COVID-19. Western blot analysis. Cell line: HEK293T cells. Concentration: 0.5 nM Incubation time: 24 hours. Result: Reduced the acetylation status of Ndufa9 and SOD2.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Sirtuin