Nicotinamide

SKU: orb1310155

Description

Nicotinamide

Research Area

Epigenetics & Chromatin, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 98-92-0
• MW: 122.1
• Purity: >99%
• Formula: C₆H₆N₂O
• SMILES: NC(=O)C1=CN=CC=C1
• Target: Protein deacetylase
• Solubility: Soluble in DMSO (up to 50 mg/ml) or in Water (up to 50 mg/ml)

Bioactivity

• Target IC50:
  HEK293T cells:43.8 μM|BL21 cells:6.2 μM|RAW 264.7 cells:> 10 μM|MDA-MB-231 cells:20.09 mM|MCF-7 cells:20.01 mM|SK-MEL-28 cells:100 μM|SIRT2:2 μM (EC50)|MDA-MB-436 cells:30.09 mM|Sir2Tm-D101N mutant:14.6 ± 3.4 mM|SIRT1:50-180 μM
• In Vivo:
  METHODS: To study the anti-tumor activity of Nicotinamide, mice were intraperitoneally injected with Nicotinamide (1500 and 1800 mg/Kg, 5 days a week). RESULTS: Nicotinamide inhibited tumor growth ina mouse model of metastatic melanoma. METHODS: To study the antiviral activity of Nicotinamide, Nicotinamide (0-200 mg/kg, 5 days) was intraperitoneally injected into HBV transgenic mice. RESULTS: Nicotinamide inhibited HBV replication in HBV transgenic mice.
• In Vitro:
  METHODS: A375, SK-MEL-28, and mouse B16-F10 cells were treated with Nicotinamide (0, 1, 20, and 50 mM) for 24 or 48 hours. RESULTS: Nicotinamide reduced cell numbers ina dose-dependent manner, with a strong inhibitory effect at 20mM and almost full effect at 50mM.

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Nicotinic acid amide; Niacinamide; Vitamin B3, NAM

Compound Identifiers

PubChem CID

936