Nicorandil

SKU: orb1310965

Description

Nicorandil

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 65141-46-0
• MW: 211.17
• Purity: 98.52%
• Formula: C₈H₉N₃O₄
• SMILES: [O-][N+](=O)OCCNC(=O)C1=CN=CC=C1
• Target: Potassium Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.47 mM);H2O:80.5 mM;DMSO:50 mg/mL (236.78 mM)

Bioactivity

• In Vitro:
  Nicorandil (100 mM) increases Flavoprotein oxidation but not membrane current; a 10-fold higher concentration recruits both mitoK(ATP) and surfaceK(ATP) channels. Nicorandil bluntes the rate of cell death in a pelleting model of ischemia; this cardioprotective effect is prevented by the mitoK(ATP) channel blocker 5-hydroxydecanoate but is unaffected by the surfaceK(ATP) channel blocker HMR1098. Nicorandil (100 mM) suppresses TUNEL positivity, cytochrome c translocation, caspase-3 activation and dissipation of mitochondrialinner membrane potential (Delta(Psi)(m)). Nicorandil prevents Delta(Psi)(m) depolarization in a concentration-dependent manner (EC(50) approximately 40 mM, with saturation by 100 mM), as shown by fluorescence-activated cell sorter analysis of cells stained with a fluorescent Delta(Psi)(m)-indicator, tetramethylrhodamine ethyl ester (TMRE). Nicorandil activates a weakly inwardly-rectifying, glibenclamide-sensitive 80 pS K+ channel in both the transfected cells. Nicorandil preferentially activates the K(ATP) channels containing SUR2B in HEK293T cells. Nicorandil (100 mM) significantly suppresses the number of cells with TUNEL-positive nuclei and the increase in caspase-3 activity induced by 20 mM Water2. Nicorandil prevents the loss of DeltaPsim induced by Water2 in a concentration-dependent manner.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Potassium Channel, PotassiumChannel, SG75, SG-75, SG 75, vascular, vasodilatory, diseases, diphosphate-dependent, cardioprotective, channels, ATP, angina, forischemic, heart, Inhibitor, KATP, inhibit, KcsA, Nicorandil, nucleoside

Compound Identifiers

PubChem CID

47528