Nicaraven

SKU: orb1300620

Description

Nicaraven

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 79455-30-4
• MW: 284.31
• Purity: 99.77%
• Formula: C₁₅H₁₆N₄O₂
• SMILES: CC(CNC(=O)c1cccnc1)NC(=O)c1cccnc1
• Target: Others,ROS
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.03 mM);H2O:52 mg/mL (182.9 mM);Ethanol:53 mg/mL (186.42 mM);DMSO:45 mg/mL (158.28 mM)

Bioactivity

• In Vivo:
  Nicaraven inhibits lipid peroxidation in the liver of beagle dogs, improves hepatic and systemic hemodynamics and energy metabolism, and suppresses liver enzyme release, endothelin-1 elevation in hepatic venous blood, histologic damage, and neutrophil infiltration into the liver . Nicaraven (20 mg/kg) slightly reduces infarction volume in male Sprague-Dawley rats subjected to transient focal ischemia, while a dose of 60 mg/kg significantly reduces infarction volume by 18.6% and 20.9% in pre- and posttreatment groups, respectively .
• In Vitro:
  Nicaraven causes a dose-dependent, slight inhibition of poly (ADP-ribose) synthetase activation, possibly due to a direct inhibitory effect on the catalytic activity of poly (ADP-ribose) synthetase in RAW murine macrophages stimulated with peroxynitrite. Nicaraven partially protects against the peroxynitrite-induced suppression of mitochondrial respiration in RAW macrophages and causes a slight, dose-dependent inhibition of nitrite production in RAW macrophages stimulated with bacterial lipopolysaccharide. Nicaraven (0.35 mM) significantly inhibits the maximum aggregation rate induced by adenosine diphosphate (ADP) in the healthy volunteer platelets. Nicaraven (1.75 mM) significantly reduces the maximum aggregation rate induced by collagen in platelets. Nicaraven induces dose-dependent inhibition of platelet aggregation in both healthy volunteers and patients with cerebral thrombosis.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Nicaraven, inhibit

Compound Identifiers

PubChem CID

71234