Nic-15

SKU: orb2665352

Description

Nic-15 (compound 4n) is a small molecule that targets the low vascularity of pancreatic tumors, modulating the PI3K/Akt/mTOR pathway and alleviating ER stress to overcome gemcitabine resistance. It inhibits migration and colony formation in MIA PaCa-2 and PANC-1 cells and enhances gemcitabine efficacy in xenograft models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2896739-91-4
• MW: 412.47
• Formula: C₂₅H₂₆F₂O₃
• SMILES: C(=O)([C@H]1[C@@H](CC(CCC=C(C)C)=CC1)C2=C(F)C(F)=CC=C2)C3=C(O)C=CC=C3O
• Target: mTOR,PI3K,Akt

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172420085