NIC-12

SKU: orb2565680

Description

NIC-12 is a selective NLRP3 inflammasome inhibitor. It effectively lowers plasma IL-1β in LPS-challenged mice and suppresses NLRP3 activation in murine macrophages, making it a valuable tool for studying inflammation in both in vivo endotoxemia models and in vitro cellular assays.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 2409826-23-7
• MW: 462.01
• Formula: C₂₂H₂₈ClN₅O₂S
• SMILES: C(C)(C)C=1N2C3=C(C=C2C(=O)N(CC(N[C@H]4CN(CC5CC5)CCC4)=O)N1)SC(Cl)=C3
• Target: NOD-like Receptor (NLR)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

146308301