NIBR-LTSi

SKU: orb2695182

Description

NIBR-LTSi is a selective LATS kinase inhibitor that activates YAP signaling. It promotes stem cell expansion and tissue regeneration, accelerating liver repair in mouse hepatectomy models and enabling the growth of diverse mouse and human organoids for regenerative research.

Research Area

Stem Cell & Developmental Biology

Key Properties

• MW: 308.38
• Purity: 99.87% (May vary between batches)
• Formula: C₁₈H₂₀N₄O
• SMILES: C1CNC[C@H](C1)Oc1ccc(Nc2ccnc3[nH]ccc23)cc1
• Target: YAP
• Solubility: DMSO:1 mg/mL (3.24 mM)

Bioactivity

• In Vivo:
  Methods: Mice were treated with NIBR-LTSi (30, 100 mg/kg, oral administration) to study the later stages of liver regeneration. Results: NIBR-LTSi resulted in significant dose-dependent growth of organoids starting 48 hours after initial treatment and showed reduced expression of the mature podocyte marker WT1 and increased serum blood urea nitrogen (BUN) levels.
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• In Vitro:
  Methods: A human 3D skin model was treated with NIBR-LTSi (1, 3, 10 μM, 3 days) to evaluate its proliferative effects. Results: NIBR-LTSi treatment resulted in a dose-dependent increase in keratinocyte proliferation. In addition, NIBR-LTSi-induced YAP signaling impeded the differentiation of human keratinocytes.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

175663140