NIBR-17

SKU: orb1305962

Description

NIBR-17 is a potent pan-class I PI3K inhibitor, exhibiting low nanomolar IC50 values against the PI3Kα, β, γ, and δ isoforms. This compound is a valuable research tool for investigating PI3K signaling in oncology and immunology, applicable in both cellular and in vivo model systems.

Research Area

Signal Transduction

Key Properties

• CAS Number: 944396-88-7
• MW: 380.4
• Purity: 97.79% (May vary between batches)
• Formula: C₁₈H₂₀N₈O₂
• SMILES: COc1ccc(Nc2cc(nc(n2)N2CCOCC2)-c2cnc(N)nc2)cn1
• Target: PI3K
• Solubility: DMSO:55 mg/mL (144.58 mM)

Bioactivity

• Target IC50:
  PI3Kβ:9.2 nM|PI3Kα:1 nM|PI3Kγ:9 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NIBR 17, NIBR17, NIBR-17, inhibit, Inhibitor, PI3kα, PI3kβ, PI3K, PI3kδ, PI3kγ, Phosphoinositide 3-kinase

Compound Identifiers

PubChem CID

53322732