NI-42

SKU: orb1307964

Description

NI-42 is a structurally orthogonal and biased chemical probe that potently and selectively inhibits the bromodomains of BRPF1, BRPF2, and BRPF3. This tool compound is valuable for investigating the roles of BRPF proteins in epigenetic regulation, cancer biology, and both in vitro and in vivo disease models.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1884640-99-6
• MW: 353.39
• Purity: 99.18% (May vary between batches)
• Formula: C₁₈H₁₅N₃O₃S
• SMILES: Cc1cc2cc(NS(=O)(=O)c3ccc(cc3)C#N)ccc2n(C)c1=O
• Target: Epigenetic Reader Domain
• Solubility: DMSO:95 mg/mL (268.82 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.34 mM)

Bioactivity

• Target IC50:
  BRD9:1130 nM (kd)|BRD9:310 nM|BRD4 BD1:4500 nM|BRD7:82 nM|BRPF3:260 nM|BRPF3:940 nM (kd)|BRPF2:210 nM (kd)|BRPF2:48 nM|BRPF1:40 nM (kd)|BRPF1:7.9 nM
• In Vitro:
  NI-42 displays IC50s of 82, 310, and 4500 nM for BRD7, BRD9, and BRD4 (BD1), respectively. It has a Kd of 1130 nM for BRD9.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BRD7, BRD9, BRD4 BD1, BD1-BRD4, BRPF2, BRPF1, BRPF3, Epigenetic Reader Domain, EpigeneticReaderDomain, inhibit, Inhibitor, NI 42, NI42, NI-42

Compound Identifiers

PubChem CID

118933132