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NHEJ inhibitor-1

SKU: orb1982880

Description

NHEJ Inhibitor-1 (Compound C2) is a trifunctional platinum complex that overcomes cisplatin resistance in NSCLC by inhibiting Ku70 and Rad51-mediated DNA repair pathways. It further induces ROS production and reduces mitochondrial membrane potential, demonstrating efficacy in both cellular and animal models of lung cancer.

Research Area

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

MW848.79
FormulaC30H35N7O8PtS
TargetReactive Oxygen Species,Others

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

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Protocol Information