NH2-methylpropanamide-Exatecan TFA

SKU: orb2279051

Description

Exatecan TFA is a methylpropanamide-modified derivative of the cytotoxin Exatecan, functioning as a potent DNA topoisomerase I inhibitor with an IC50 of 2.2 µM. It is widely used in the synthesis of antibody-drug conjugates (ADCs) for targeted cancer therapy research, applicable in both in vitro biochemical assays and in vivo preclinical studies.

Research Area

Immunology & Inflammation; Pharmacology & Drug Discovery, Molecular Biology

Key Properties

• CAS Number: 1817857-35-4
• MW: 634.58
• Formula: C₃₀H₃₀F₄N₄O₇
• SMILES: C(C(O)=O)(F)(F)F.N(C([C@H](CN)C)=O)[C@@H]1C2=C3C(C=4N(C3)C(=O)C5=C(C4)[C@](CC)(O)C(=O)OC5)=NC=6C2=C(CC1)C(C)=C(F)C6
• Target: ADC Cytotoxin|||Topoisomerase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168510631