NGP555

SKU: orb1307969

Description

NGP555 is a γ-secretase modulator investigated for its potential role in Alzheimer's disease research. It has been utilized in both in vitro and in vivo studies to selectively modulate amyloid-β peptide production without inhibiting overall γ-secretase activity.

Research Area

Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1304630-27-0
• MW: 406.52
• Purity: 99.86%
• Formula: C₂₃H₂₃FN₄S
• SMILES: CCc1cc(Nc2nc(cs2)-c2ccc(c(F)c2)-n2cnc(C)c2)c(C)cc1C
• Target: Gamma-secretase
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (4.92 mM);DMSO:25 mg/mL (61.5 mM)

Bioactivity

• In Vivo:
  NGP555 also shows good oral bioavailability and is brain-penetrant with a brain: plasma ratio of ~0.93 in mice. NGP555-treated Tg mice show significant protection from a decline in performance with >65% less decline (P<0.005) when comparing the differential of Tg to non-Tg vehicle-treated mice. NGP555 obviously lowers Aβ42 in the cerebrospinal fluid (CSF) at time points from 8 to10 hours post-dose. When combining the reduction of Aβ42 with an increase in Aβ38, NGP555 is effective at raising CSF Aβ38/42 ratio at 1.87 mg/kg and above .
• In Vitro:
  NGP555 effectively lowers Aβ42 in cell cultures (9 nM) and increasing shorter forms of Aβ at the same time .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Gammasecretase, Gamma secretase, Inhibitor, inhibit, NGP 555, NGP555, NGP-555, γ secretase, γ-secretase

Compound Identifiers

PubChem CID

46853593