NG-497

SKU: orb1744118

Description

NG-497 is a selective small-molecule inhibitor that targets the patatin-like domain of human adipose triglyceride lipase (ATGL), reversibly suppressing cellular lipolysis. Its application in cancer research is supported by studies investigating the role of lipid metabolism in tumor progression, both in vitro and in vivo.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2598242-66-9
• MW: 315.36
• Purity: 99.57%
• Formula: C₁₈H₂₁NO₄
• SMILES: C(OC(C)C)(=O)C1=NC(=CC(OC)=C1)C2=CC=C(OCC)C=C2
• Target: Lipase
• Solubility: DMSO:50 mg/mL (158.55 mM)

Bioactivity

• In Vitro:
  NG-497 selectively inactivates human and non-human primate ATGL, but not structurally and functionally related lipid hydrolases, and eliminates human adipocytes in a dose-dependent and reversible manner. Lipolysis. NG-497 (40 μM, 80 min) reduces lipolysis-dependent respiration in HepG2 cells without impairing mitochondrial function through off-target effects.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ATGL, NG497, NG-497, NG 497

Compound Identifiers

PubChem CID

155594277