NFI23

SKU: orb3211425

Description

NFI23 is a GluN2B-NMDAR inhibitor with an IC50 of 1.31 μM and a Ki of 5.98 nM. It can cross the blood-brain barrier and binds to the ifenprodil binding site of GluN2B-NMDAR, reducing NMDA-induced Ca2+ influx and reactive oxygen species (ROS) production. It helps maintain mitochondrial membrane potential, inhibits neuronal apoptosis, and restores p-ERK1/2 expression. NFI23 demonstrates neuroprotective effects against NMDA-induced cytotoxicity and in a rat model of middle cerebral artery occlusion (MCAO), making it useful for ischemic stroke research.

Key Properties

• Target: iGluR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

iGluR