NF-κB-IN-20

SKU: orb3173120

Description

NF-κB-IN-20 is an orally bioavailable inhibitor of NF-κB. By binding directly to the Keap1 protein, NF-κB-IN-20 activates the Keap1/Nrf2/HO-1 antioxidant pathway and concurrently inhibits the NF-κB inflammatory pathway, working synergistically to reduce oxidative stress and inflammation. Additionally, NF-κB-IN-20 M11 suppresses the expression of IL-6, IL-1β, and TNF-α, significantly decreases ROS levels, and restores mitochondrial membrane potential. This compound is applicable in studies of acute lung injury (ALI).

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Key Properties

• Target: Interleukin,Nrf2,TNF,ROS,NF-κB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Interleukin,Nrf2,TNF,ROS,NF-κB