NF-κB-IN-14

SKU: orb3133284

Description

NF-κB-IN-14 (compound 5e) inhibits nitric oxide production in macrophages induced by LPS, with an IC50 of 6.4 μM. It disrupts the interaction between TLR4 and MyD88 proteins, thereby inhibiting the NF-κB signaling pathway. Additionally, NF-κB-IN-14 reduces ear edema and inflammation in a mouse model of atopic dermatitis.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 3019972-01-8
• MW: 319.19
• Formula: C₁₅H₁₂Cl₂N₄
• SMILES: C(/C=C/C1=CC=C(C)C=C1)N2C=3C(N=C2)=C(Cl)N=C(Cl)N3
• Target: TLR,NF-κB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

TLR,NF-κB