NF-κΒ activator 2

SKU: orb1303465

Description

NF-κΒ activator 2

Research Area

Signal Transduction

Key Properties

• CAS Number: 2375281-44-8
• MW: 298.27
• Purity: 99.32% (May vary between batches)
• Formula: C₁₆H₁₁FN₂O₃
• SMILES: OC(=O)c1cccc(c1)-c1cnc(Nc2ccccc2F)o1
• Target: NF-κB
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (16.76 mM);DMSO:250 mg/mL (838.17 mM)

Bioactivity

• Target IC50:
  NF-κB:1.58 μM (EC50)
• In Vivo:
  NF-κΒ activator 2, when administered intravenously (i.v.) at a dose of 1 mg/kg, demonstrates an appropriate half-life of 0.96 hours in mice . Similarly, at an oral (p.o.) dosage of 5 mg/kg, it shows a comparable half-life of 2.86 hours, an oral bioavailability of 15.6%, and a maximum concentration (C max) of 92 ng/mL .
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• In Vitro:
  NF-κB activator 2 (Compound 61) (1 μM, 6 hr) induces SOD 2 mRNA expression in SH-SY5Y neuroblastoma cells . SOD2 is a highly inducible SOD that performs in concurrence with SOD1 to detoxify ROS. Induction of SOD2 can be obtained through the activation of NF-ҡBs.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

amyotrophic, ALS, Inhibitor, lateral, NFkB, NF-kappabeta activator 2, NF κΒ activator 2, NF-?B, NF-kB, NF-kb activator 2, NFκB, NF-κB, NFκΒ activator 2, NF-κΒ activator 2, Nuclear factor-κB, Nuclear factor-kappaB, inhibit, SOD2, sclerosis

Compound Identifiers

PubChem CID

139434520