NF-56-EJ40

SKU: orb1309342

Description

NF-56-EJ40 is a potent and selective human SUCNR1 (GPR91) antagonist, exhibiting an IC50 of 25 nM and a Ki of 33 nM. This tool compound is valuable for investigating the role of succinate signaling in metabolic disorders, inflammation, and hypertension in both cellular and animal models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2380230-73-7
• MW: 443.54
• Purity: 99.65% (May vary between batches)
• Formula: C₂₇H₂₉N₃O₃
• SMILES: CN1CCN(Cc2ccc(cc2)-c2cccc(c2)C(=O)Nc2ccccc2CC(O)=O)CC1
• Target: Succinate Receptor 1 (SUCNR1)
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:2 mg/mL (4.51 mM)

Bioactivity

• In Vitro:
  NF-56-EJ40 shows a high affinity for humanized rat SUCNR1 with a Ki value of 17.4 nM. NF-56-EJ40 shows almost no activity towards rat SUCNR1.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GPR91, Inhibitor, inhibit, NF56EJ40, NF-56-EJ40, NF-56-EJ-40, NF 56 EJ40, SUCNR1, SUCNR1 (GPR91)

Compound Identifiers

PubChem CID

138811017