Neuropeptide W-23(human)

SKU: orb1296764

Description

Neuropeptide W-23 (human) is an endogenous agonist for the NPBW1 (GPR7) and NPBW2 (GPR8) receptors. It is utilized in research to investigate energy homeostasis, stress responses, and neuroendocrine functions in both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 383415-79-0
• MW: 2584.01
• Purity: 98.50% (May vary between batches)
• Formula: C₁₁₉H₁₈₃N₃₅O₂₈S
• SMILES: C([C@@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(N[C@@H](CC2=CN=CN2)C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N3[C@H](C(N[C@H](C(N[C@@H](CC4=CC=C(O)C=C4)C(N[C@@H](CC5=CN=CN5)C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC(C)C)C(O)=O)=O)=O)CCSC)=O)CC(C)C)=O)CC(C)C)=O)=O)C)=O)C)=O)CCCNC(=N)N)=O)=O)[C@@H](C)C)=O)[C@@H](C)O)=O)=O)=O)CCCNC(=N)N)=O)CCC3)CO)=O)C)=O)[C@H](C)C)=O)=O)CCCCN)=O)=O)N)C=6C=7C(NC6)=CC=CC7
• Target: Others,Neuropeptide W
• Solubility: H2O:Soluble

Bioactivity

• In Vivo:
  NPW-23 increases pressure-induced vasotone of the rat mesenteric arteries. Importantly, the expression of NPW is decreased in the hypertensive rats. NPW-23 (0.3 nmol, 1.0 nmol, and 3.0 nmol) induces significant increases in mean arterial pressure (MAP) in conscious, freely moving male rats. Rats that receive either 1.0 or 3.0 nmol NPW-23 demonstrate a significant increase in total activity, ambulatory activity, and duration of stereotypy. NPW-23 fails to elevate MAP in rats pretreated with phentolamine. NPW-23-induced increases in total activity, ambulatory activity, and duration of stereotypy are reduced significantly by pretreatment with the orexin type 1 receptor (OX1R) antagonist, SB-408124 which suggests that orexin neurons are downstream targets of NPW .
• In Vitro:
  NPW-23 increases the ICa,L in transfected human embryonic kidney 293 cells and VSMCs via GPR7 which may involve in the development of vascular hypertension. NPW-23 increases the expression of pan phospho-PKC, intracellular diacylglycerol level, and the second messenger catalyzed by PLC.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anorexigenic effect, Neuropeptide W, Neuropeptide W 23(human), Neuropeptide W-23, Neuropeptide W-23 (human), Neuropeptide W23(human), NPBW1, NPBW2, NPW 23, NPW23, NPW-23, inhibit, Inhibitor, GPR8, GPR7, hypetension

Compound Identifiers

PubChem CID

16209885