Neurodazine

SKU: orb1706917

Description

Neurodazine is a small molecule neural inducer that drives pluripotent cell differentiation into neurons by activating Wnt and Shh signaling pathways. It is a valuable research tool for studying neurogenesis in both in vitro stem cell models and in vivo developmental studies.

Research Area

Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 937807-66-4
• MW: 456.92
• Purity: 98.01% (May vary between batches)
• Formula: C₂₇H₂₁ClN₂O₃
• SMILES: COc1ccc(cc1)-c1nc([nH]c1-c1ccc(OC)cc1)-c1ccc(o1)-c1cccc(Cl)c1
• Target: Wnt/beta-catenin,Hedgehog/Smoothened
• Solubility: DMSO:80 mg/mL (175.09 mM)

Bioactivity

• In Vitro:
  Treatment with Neurodazine (5 μM; 1-10 d) induces the expression of neuron-specific markers in P19 cells. Neurodazine selectively suppresses astrocyte differentiation of P19 cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Wnt/betacatenin, Wnt/b-catenin, Wnt, Wnt/β-catenin, βcatenin, Neurodazine, bcatenin, beta-catenin, betacatenin

Compound Identifiers

PubChem CID

16112820