Netivudine

SKU: orb1689485

Description

Netivudine is a nucleoside reverse transcriptase inhibitor (NRTI) analog with activity against both HIV and varicella-zoster virus (VZV). It functions by inhibiting viral reverse transcriptase, thereby reducing viral replication. This compound is utilized in antiviral research for in vitro and in vivo studies targeting retroviruses and herpesviruses.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 84558-93-0
• MW: 282.25
• Purity: 99.62% (May vary between batches)
• Formula: C₁₂H₁₄N₂O₆
• SMILES: O=C1N(C=C(C#CC)C(=O)N1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O
• Target: HSV,Nucleoside Antimetabolite/Analog
• Solubility: DMSO:55 mg/mL (194.86 mM)

Bioactivity

• Target IC50:
  VZV:0.6-3.8μM
• In Vivo:
  The half-life of netivudine in humans is about 12-15 hand preliminary pharmacokinetic studies, employing oral doses of netivudine at 100 mg, 200 mg and 400 mg in young adults and healthy elderly volunteers, confirmed that concentrations of the drug substantially above the IC50 for VZV could be achieved and sustained with twice daily dosing. The drug bioavailability was 21.1% and 24.6% in the young and elderly, respectively. An initial, open, dose-ranging study of netivudine in 31 elderly immunocompetent patients with localised herpes zoster with oral doses up to 200mg twice daily showed therapeutic benefits upon rash healing and pain and no significant adverse effects.
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• In Vitro:
  The phosphorylation of netivudine in VZV infected human cells is similar to that of sorivudine and the IC50 of netivudine for VZV ranges from 06-3.8 uM. Since, in HSV-infected cells, only the monophosphate is formed, netivudine shows no appreciable in vitro activity against HSV or other human herpesviruses.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NucleosideAntimetabolite, Nucleoside Antimetabolite, Nucleoside Analogue, Analog

Compound Identifiers

PubChem CID

55281