Neticonazole

SKU: orb1694668

Description

Neticonazole (SS717) is an imidazole-derived antifungal agent that suppresses exosome secretion. It exhibits dual anti-infective and anti-cancer properties and serves as a research tool for studying cutaneous Candida albicans infections, including associated models of contact dermatitis in vivo and in vitro.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 130726-68-0
• MW: 302.43
• Purity: 99.58%
• Formula: C₁₇H₂₂N₂OS
• SMILES: C(=C\SC)(\C1=C(OCCCCC)C=CC=C1)/N2C=CN=C2
• Target: Antifungal
• Solubility: DMSO:200 mg/mL (661.31 mM);1M HCl:80 mg/mL (264.52 mM)

Bioactivity

• Target IC50:
  Exosome:
• In Vivo:
  A clinical isolate of C. albicans, isolate KC-36, was used for production of experimental cutaneous candidiasis in guinea pigs. The MICs of Neticonazole for the test strain were 0.0625.
• In Vitro:
  Neticonazole against 39 T. rubrum isolates (MIC80, 0.125 μg/ml) and 28 T. mentagrophytes isolates (MIC80, 0.25 μg/ml). Neticonazole against 39 T. rubrum isolates (MFC80, 0.25 μg/ml) and 28 T. mentagrophytes isolates (MFC 80, 0.25 μg/ml).

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

fungal, Neticonazole, SS 717, SS717, SS-717

Compound Identifiers

PubChem CID

5282433