β-NETA

SKU: orb1308670

Description

β-NETA is a stable, slowly reversible inhibitor of choline acetyltransferase (ChAT; IC50=9 µM) and a potent CMKLR1 antagonist, exhibiting anticancer activity in research models. It also weakly inhibits cholinesterases. This compound is used in oncology and neuropharmacology research, including in vitro and in vivo studies of tumor progression and inflammation.

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 31059-54-8
• MW: 369.24
• Purity: 98.00%
• Formula: C₁₆H₂₀INO
• SMILES: [I-].C[N+](C)(C)CCC(=O)c1ccc2ccccc2c1
• Target: Apoptosis,Cholinesterase (ChE)
• Solubility: DMSO:31.25 mg/mL (84.63 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.42 mM)

Bioactivity

• Target IC50:
  AChE:300 μM|ChE:84 μM|ChAT:9 μM
• In Vivo:
  a-NETA (s.c. injection; 3 mg/kg or 10 mg/kg; daily; for 30 days) significantly delays the onset of EAE with 3 mg/kg, and completely suppresses clinical signs for an average of nine days with 10 mg/kg beyond the first appearance of disease in control female C57BL/6 mice. a-NETA (injected intraperitoneally; 0.125 mg/kg; once every other day for 20 days) significantly decreases tumor volume and tumor weight.
• In Vitro:
  a-NETA treatment increases EOC cell expression of pyroptosis-associated proteins. a-NETA (50-150 nM; 24 hours) decreases all cell lines viability in a dose-dependent manner . a-NETA (2.5-10.0 μg/mL; 24 hours) leads to epithelial ovarian cancer (EOC) cell death associated with membrane blistering and cytoplasm leakage.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, KCl, Inhibitor, histamine, ChA, ChAT, ChE, choline acetyltransferase, cholinesterase, Cholinesterase (ChE), CMKLR1, b-NETA, beta-NETA, Apoptosis, a-NETA, AChE, acetylcholinesterase, alpha-NETA, α-NETA, β NETA, βNETA, β-NETA

Compound Identifiers

PubChem CID

169245