Nestorone

SKU: orb1224021

Description

Nestoron2 (ST1435, Elcometrine) is a 19-norprogesterone derivative and steroidal progestin which is used as a hormonal contraceptive, a high-affinity agonist of the progesterone receptor.Other Indication Discontinued(In Vivo):Nestoron (400 μCi 3H Nestoron/kg BW; subcutaneous injection; female Sprague-Dawley rats) treatment results in the Cmax in the blood and plasma are 58.1 and 95.5 ng equiv. 3H Nestoron/g, with t1/2 of 15.6 hours. Approximately, 81.4% and 7.62% of the administered dose is excreted via feces and urine, respectively.

Key Properties

• CAS Number: 7759-35-5
• MW: 370.4819
• Purity: >98% (HPLC)
• Formula: C₂₃H₃₀O₄
• SMILES: CC([C@@]1(OC(C)=O)C(C[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4([H])[C@@]3([H])CC[C@]12C)=O)=C)=O
• Target: Prostaglandin Receptor
• Solubility: 10 mM in DMSO

Bioactivity

• In Vivo:
  Nestoron (400 μCi 3H Nestoron/kg BW; subcutaneous injection; female Sprague-Dawley rats) treatment results in the Cmax in the blood and plasma are 58.1 and 95.5 ng equiv. 3H Nestoron/g, with t1/2 of 15.6 hours. Approximately, 81.4% and 7.62% of the administered dose is excreted via feces and urine, respectively. Animal model: 27 adult, female, Sprague-Dawley rats (200-225 g; age: 8 weeks). Dosage: 400 μCi 3H Nestorone/kg BW. Administration: Subcutaneous injection (Pharmacokinetic study). Result: The mean peak concentrations of radioactivity (Cmax) in the blood and plasma were 58.1 and 95.5 ng equiv. /g, with t1/2 of 15.6 hours. Approximately, 81.4% and 7.62% of the administered dose was excreted via feces and urine, respectively.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Elcometrine | Nestorone | ST-1435 | ST1435

Quick Database Links

Gene Symbol

Prostaglandin Receptor