Nerol

SKU: orb1301624

Description

Nerol

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 106-25-2
• MW: 154.25
• Purity: 98.59%
• Formula: C₁₀H₁₈O
• SMILES: C(\CCC=C(C)C)(=C\CO)/C
• Target: Mitochondrial Metabolism,Antifungal,ROS,Reactive Oxygen Species,Apoptosis,Endogenous Metabolite
• Solubility: DMSO:45 mg/mL (291.73 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (12.97 mM)

Bioactivity

• In Vivo:
  Nerol primarily by reducing Ca2+ influx through L-type Ca2+ channel blockade lessened the severity of ouabain-triggered arrhythmias in mammalian heart.
• Animal Research:
  Guinea pigs were sacrificed by decapitation and hearts were removed and isolated left atrium mounted vertically in an organ baths containing Tyrode's solution of the following composition (mM): NaCl 120, KCl 2.7, MgCl2 0.9, NaHCO3 11.9, CaCl2 1.37, glucose 5.5, NaH2PO4 0.4, pH 7.4. The atria preparations were subsequently connected to Grass FI'-03 force displacement transducers to record changes in atrial contractile force. Each muscle was stretched to the length at which contractile force was maximal (1.0 gf). The atria were electrically paced at 1 Hz with pulses of 1.5 ms duration and stimulated by 70 V pulses. All preparations were allowed to equilibrate for 30 min until complete mechanical stabilization had been achieved. Nerol ( 97%) was freshly solubilized in 0.5% DMSO and cumulatively added to bath chambers. After each observation, muscles were washed several times and allowed to recover for 30 minutes until their mechanical function completely returned to control values. DMSO at this concentration did not show any significant effect on the variables measured (data not shown, n = 5).

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ROS, Reactive Oxygen Species, ReactiveOxygenSpecies, Antifungal, Apoptosis, Calcium, dysfunction, Cis-Geraniol, MitochondrialMetabolism, mitochondrial, Mitochondrial Metabolism, Nerol, Neryl alcohol, NEL, inhibit, Fungal, Endogenous Metabolite, EndogenousMetabolite, Inhibitor

Compound Identifiers

PubChem CID

643820