Neoprzewaquinone A

SKU: orb3023821

Description

Neoprzewaquinone A (NEO), a bioactive compound from Salvia miltiorrhiza, acts as a dual PIM1 kinase inhibitor and ROCK2/STAT3 pathway blocker. This small molecule is a valuable research tool for studying breast cancer cell migration and metastasis in vitro, as well as mechanisms of vascular smooth muscle relaxation.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 630057-39-5
• MW: 556.6
• Purity: 97.49% (May vary between batches)
• Formula: C₃₆H₂₈O₆
• SMILES: Cc1coc-2c1C(=O)C(=O)c1c-2ccc2c1CCCC(=C)c1ccc3-c4occ(C)c4C(=O)C(=O)c3c1CC\C=C2/C
• Target: STAT,ROCK,Pim
• Solubility: DMSO:4.5 mg/mL (8.08 mM)

Bioactivity

• In Vitro:
  The active ingredient Neoprzewaquinone A (NEO) in crocetin selectively inhibits PIM1,a phenomenon observed at nanomolar concentrations. NEO effectively inhibits the PIM1 kinase and significantly suppresses the growth, migration, and epithelial-mesenchymal transition (EMT) of the triple-negative breast cancer cell line MDA-MB-231 in vitro .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antifection, Neoprzewaquinone A, Pim1;ROCK2;STAT3

Quick Database Links

Gene Symbol

STAT,ROCK,Pim