Neoprzewaquinone A

SKU: orb3023821

Description

Neoprzewaquinone A (NEO), an active ingredient of S. miltiorrhiza, inhibits breast cancer cell migration and promotes smooth muscle relaxation by targeting PIM1 and blocking the ROCK2/STAT3 pathway.

Key Properties

• CAS Number: 630057-39-5
• MW: 556.6
• Formula: C₃₆H₂₈O₆
• SMILES: Cc1coc-2c1C(=O)C(=O)c1c-2ccc2c1CCCC(=C)c1ccc3-c4occ(C)c4C(=O)C(=O)c3c1CC\C=C2/C
• Target: STAT,ROCK,Pim
• Solubility: DMSO:4.5 mg/mL (8.08 mM)

Bioactivity

• In Vitro:
  The active ingredient Neoprzewaquinone A (NEO) in crocetin selectively inhibits PIM1,a phenomenon observed at nanomolar concentration . NEO effectively inhibit the PIM1 kinase and significantly suppresse the growth, migration, and epithelial-mesenchymal transition (EMT) o the triple-negative breast cancer cell line MDA-MB-231 in vitro.

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Antifection, Neoprzewaquinone A, Pim1;ROCK2;STAT3

Quick Database Links

Gene Symbol

STAT,ROCK,Pim