Neoline

SKU: orb1302356

Description

Neoline, an active component from A. venetum root (PA), alleviates oxaliplatin-induced peripheral neuropathy in murine models by inhibiting Nav1.7 voltage-gated sodium channels. This small molecule serves as a useful analytical marker for PA product quality in neuropathic pain research, with applications in both in vivo behavioral studies and in vitro electrophysiology assays.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 466-26-2
• MW: 437.57
• Purity: 99.97% (May vary between batches)
• Formula: C₂₄H₃₉NO₆
• SMILES: [H][C@]12C[C@]3([H])[C@]([H])([C@H]1O)[C@](O)(C[C@@H]2OC)[C@@]1([H])[C@H](OC)[C@@]2([H])C33[C@@H](O)CC[C@@]2(COC)CN(CC)[C@]13[H]
• Target: Sodium Channel
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.43 mM);DMSO:200 mg/mL (457.07 mM)

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bullatine B, Inhibitor, pain, neuropathic, neuropathy, Neoline, Nav1.7 channel, inhibit, peripheral, oxaliplatin-induced, SodiumChannel, Sodium Channel

Compound Identifiers

PubChem CID

135393463