Neoisoastilbin

SKU: orb1297269

Description

trans-3-Indoleacrylic acid is an endogenous metabolite that acts as a ferroptosis inhibitor, countering the effects of RSL3. It serves as a valuable research tool for investigating ferroptosis mechanisms and related pathologies, including colorectal cancer, in both cellular and animal models.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 54141-72-9
• MW: 450.39
• Purity: >99.99% (May vary between batches)
• Formula: C₂₁H₂₂O₁₁
• SMILES: C[C@@H]1O[C@@H](O[C@@H]2[C@@H](Oc3cc(O)cc(O)c3C2=O)c2ccc(O)c(O)c2)[C@H](O)[C@H](O)[C@H]1O
• Target: IL Receptor,NO Synthase,TNF
• Solubility: DMSO:55 mg/mL (122.12 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.44 mM)

Bioactivity

• In Vitro:
  Phenolic-enriched extract of S. glabra (PEESG) was extracted with 70% ethanol and purified by HP-20 column chromatography. Its antioxidant and anti-inflammatory activities were evaluated by radical scavenging assay, reducing power determination, and lipopolysaccharide (LPS)-induced RAW264.7 cells assays, respectively. PEESG exhibited obviously scavenging capacity for DPPH and ABTS radicals, as well as significant reducing power for ferric ion. Particularly, PEESG (12.5-50 μg/mL) showed a significantly higher efficiency for scavenging ABTS than that of ascorbic acid and no significant difference with ascorbic acid for DPPH scavenging. PEESG also possessed a significant suppression effect on proinflammatory mediators production, such as nitric oxide (NO), tumor necrosis factor-α± (TNF-α±), and interleukin-6 (IL-6), in LPS-induced RAW264.7 cells. In addition, the main ingredients of PEESG were identified using ultrahigh pressure liquid chromatography coupled to electrospray mass spectrometry (U-HPLC-ESI-MS). Seventeen components, including 5-O-caffeoylshikimic acid, neoastilbin, astilbin, Neoisoastilbin, isoastilbin, engetin and isoengeletin were identified.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TNF-α, inhibit, NOSynthase, Inhibitor, ILReceptor, IL Receptor, Neoisoastilbin, NO Synthase

Compound Identifiers

PubChem CID

10114809