Neohesperidin

SKU: orb1305092

Description

Neohesperidin (NSC-31048) is a citrus-derived flavanone exhibiting antioxidant and neuroprotective activities in vitro and in vivo. While it shares structural similarity with other flavanones, it uniquely did not demonstrate inhibitory effects on oral carcinogenesis in a rat model, highlighting its specific research applications in neuroscience and oxidative stress studies.

Research Area

Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 13241-33-3
• MW: 610.56
• Purity: 98.53%
• Formula: C₂₈H₃₄O₁₅
• SMILES: O=C1C=2C(O[C@@H](C1)C3=CC(O)=C(OC)C=C3)=CC(O[C@H]4[C@H](O[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)[C@@H](O)[C@H](O)[C@@H](CO)O4)=CC2O
• Target: Antioxidant,Wnt/beta-catenin
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:100 mg/mL (163.78 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.55 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  Neohesperidin, administered at a dose of 50 mg/kg, significantly reduces the occurrence of HCl/ethanol-induced gastric lesions by 55.0%. In studies involving pylorus-ligated rats, this compound notably decreases both the volume of gastric secretion and gastric acid output, while simultaneously increasing gastric pH. Additionally, neohesperidin treatment markedly improves glucose metabolism and insulin sensitivity in diabetic mice, evidenced by substantial reductions in fasting glucose, serum glucose, glycosylated serum protein (GSP), serum triglycerides, total cholesterol, and leptin levels, alongside a decrease in the liver index. It also enhances oral glucose tolerance and reduces insulin resistance in these mice.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Hesperetin 7-O-neohesperidoside, inhibit, Inhibitor, NSC 31048, Neohesperidin, NSC31048, NSC-31048, antioxidant

Compound Identifiers

PubChem CID

442439