Neoglycyrol

SKU: orb1297270

Description

Aminomalonic acid is an endogenous amino acid metabolite and a potent in vitro inhibitor of L-asparagine synthetase, with potential applications as a biomarker in melanoma metastasis research. Its inhibitory activity has been demonstrated in studies using Leukemia 5178Y/AR and mouse pancreas cell lines.

Key Properties

• CAS Number: 23013-84-5
• MW: 366.36
• Purity: 98.39% (May vary between batches)
• Formula: C₂₁H₁₈O₆
• SMILES: COc1c(CC=C(C)C)c(O)cc2oc(=O)c3c4ccc(O)cc4oc3c12
• Target: Others
• Solubility: DMSO:3.67 mg/mL (10.02 mM)

Bioactivity

• In Vitro:
  Fractions of TMYXP were prepared by high performance liquid preparation technology. The cardioprotective effects of prepared fractions were tested on H2O2 oxidation-damaged H9c2 myocardiocytes. The active components were analyzed by high performance liquid chromatography (HPLC) coupled with high resolution mass spectrometry. The possible active compounds were putatively identified by comparison of their MS ions and molecular weight with literatures. Ten TMYXP components presented significant myocardial protective activities, 5 of which were investigated and presented good dose-effect relationships. Their median effective concentrations (EC50) were respectively 11.66, 17.44, 13.10, 7.332, 15.15 μg/mL. Totally, 11 potential active compounds were analyzed and identified, including Glycyrrhizic acid, Glycycoumarin, Licoisoflavone, Ophiopogonin D', Licoricon, Gancaonin L, Neoglycyrol, Emodin, Angeloylgomisin H, Angeloylgomisin Q and Glyasperin A.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Neoglycyrol, inhibit, Inhibitor

Compound Identifiers

PubChem CID

5320083