Neocnidilide

SKU: orb1684380

Description

Neocnidilide, an alkyl phthalate from Rhizoma Ligustici Chuanxiong, exhibits antifungal activity against mycotoxin-producing fungi and insecticidal properties with an LC50 of 9.9 μmol/mL against D. melanogaster larvae. It also functions as a skin penetration enhancer, as demonstrated with benzoic acid in research applications.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 4567-33-3
• MW: 194.27
• Purity: 98.78% (May vary between batches)
• Formula: C₁₂H₁₈O₂
• SMILES: C(CCC)[C@H]1[C@]2(C(C(=O)O1)=CCCC2)[H]
• Target: Antifungal
• Solubility: DMSO:45 mg/mL (231.64 mM)

Bioactivity

• In Vitro:
  In this study, the authors compare the composition of the volatile fractions of A. graveolens collected in natural populations in Portugal and Italy and evaluate their potential as antifungal agents.The composition of the volatile oils obtained by hydrodistillation and their antifungal activity are reported. The oils were analysed by gas chromatography-flame ionisation detector and gas chromatography-mass spectrometry methods and their composition were compared with that of the volatile extracts isolated by supercritical CO2. A chemical variability in the extracts depending on the origin of the plants and on the extraction method was observed. The results showed the presence of sedanenolide, Neocnidilide and neophytadiene as main components. The minimal inhibitory concentration (MIC) and the minimal lethal concentration were used to evaluate the antifungal activity of the oils against Candida albicans, Candida tropicalis, Candida krusei, Candida guilliermondii, Candida parapsilosis, Cryptococcus neoformans, Trichophyton rubrum, Trichophyton mentagrophytes, T. mentagrophytes var. interdigitale, Trichophyton verrucosum, Microsporum canis, Microsporum gypseum, Epidermophyton floccosum, Aspergillus niger, Aspergillus fumigatus and Aspergillus flavus. The oil from Italy rich in neophytadiene is the more active, with MIC values of 0.04-0.64 μL mL(-1)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antifection, Neocnidilide, Fungal

Compound Identifiers

PubChem CID

3083857