Neochamaejasmine B

SKU: orb1297271

Description

Neochamaejasmine B is a bioactive small molecule exhibiting nematicidal effects against the pinewood nematode Bursaphelenchus xylophilus and its relative B. mucronatus. It serves as a valuable research tool for studying novel anthelmintic agents and controlling nematode infections in both in vitro and plant model systems.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 90411-12-4
• MW: 542.49
• Purity: 99.89% (May vary between batches)
• Formula: C₃₀H₂₂O₁₀
• SMILES: O=C1[C@]([C@@H](OC=2C1=C(O)C=C(O)C2)C3=CC=C(O)C=C3)([C@]4([C@H](OC=5C(C4=O)=C(O)C=C(O)C5)C6=CC=C(O)C=C6)[H])[H]
• Target: Antifection
• Solubility: DMSO:65 mg/mL (119.82 mM)

Bioactivity

• In Vitro:
  In this field, Stellera chamaejasme L. (Thymelaeaceae) is one of the most toxic and ecologically-threatening weeds in some of the grasslands of north and west China. Bioassay-guided fractionation of root extracts of this plant led to the isolation of eight flavonoids 1-8, whose structures were elucidated by spectroscopic analysis. All compounds obtained, except 7-methoxylneochaejasmin A (4) and (+)-epiafzelechin (5), showed strong phytotoxic activity against Arabidopsis thaliana seedlings. Seedling growth was reduced by neochamaejasmin B (Neochamaejasmine B,1), mesoneochamaejasmin A (2), chamaejasmenin C (3), genkwanol A (6), daphnodorin B (7) and dihydrodaphnodorin B (8) with IC50 values of 6.9, 12.1, 43.2, 74.8, 7.1 and 27.3μg/mL, respectively, and all of these compounds disrupted root development

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Stellera chamaejasme, cis-trans geometry, (+)-Neochamaejasmin B, biflavanone, Antifection, inhibit, Neochamaejasmin B, Neochamaejasmine B, Inhibitor

Compound Identifiers

PubChem CID

21636084