Neoandrographolide

SKU: orb1303611

Description

Neoandrographolide is a bioactive small molecule with significant hypolipidemic and cardiovascular protective effects, showing minimal hepatotoxicity. Its anti-inflammatory activity involves suppressing iNOS and COX-2 via p38 MAPK inhibition. Furthermore, it acts as a chemosensitizer in vitro, overcoming chemoresistance in models like XIAP-overexpressing Jurkat cells.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Molecular Biology, Neuroscience, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 27215-14-1
• MW: 480.59
• Purity: 98.52%
• Formula: C₂₆H₄₀O₈
• SMILES: C[C@@]1(CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)CCC[C@@]2(C)[C@H](CCC3=CCOC3=O)C(=C)CC[C@H]12
• Target: JNK,ROS,GSK-3,CaMK,NO Synthase,PI3K,COX,ERK,p38 MAPK,NF-κB,Apoptosis,NOS,PPAR
• Solubility: DMSO:50 mg/mL (104.04 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:10 mg/mL (20.81 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

iNOS, Inhibitor, Neoandrographiside, Neoandrographolide, inhibit, COX-2

Compound Identifiers

PubChem CID

9848024