NEO-811

SKU: orb3177580

Description

NEO-811 is a potent, selective, and cereblon (CRBN)-dependent E3 ubiquitin ligase-mediated proteolytic inhibitor that targets ARNT (HIF-1β). NEO-811 blocks ccRCC signaling pathways by promoting degradation of ARNT, thereby inhibiting tumor cell survival and proliferation. NEO-811 is used in targeted protein degradation research systems to study CRBN-dependent ubiquitination, hypoxia-inducible factor signaling regulation, and clear cell renal cell carcinoma (ccRCC) molecular pathway modulation in cellular oncology models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3084635-77-5
• MW: 543.59
• Formula: C₃₀H₃₀FN₅O₄
• SMILES: O[C@]1(C(C)(C)CN(CC2=CC=C(C=C2)C=3N=CON3)CC1)C4=C(F)C5=C(C=C4)N=CC(=C5)C6C(=O)NC(=O)CC6
• Target: Molecular Glues

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Molecular Glues