NEK7 degrader-1

SKU: orb3181307

Description

NEK7 degrader-1 is a NEK7 molecular glue degrader with a DC50 of 0.1 nM. NEK7 degrader-1 dose-dependently inhibits caspase-1 activity and IL-1β release in macrophages in response to NLRP3 inflammasome activation. NEK7 degrader-1 can be used for research on autoinflammatory and autoimmune diseases (e.g., multiple sclerosis), neurodegenerative diseases (e.g., Alzheimer's disease), and cardiovascular and pigmentation disorders (e.g., pericarditis and type 2 diabetes).

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 3069891-91-1
• MW: 449.33
• Purity: 97.02% (May vary between batches)
• Formula: C₂₁H₂₂Cl₂N₄O₃
• SMILES: O=C1NC(=O)C(C2=C(Cl)C=C(C=C2Cl)CNC(=O)C(C3=NC=C(C=N3)C)(C)C)CC1
• Target: Caspase,Molecular Glues,Serine/threonin kinase,NOD,IL Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Caspase,Molecular Glues,Serine/threonin kinase,NOD,IL Receptor