Negletein

SKU: orb1222401

Description

Negletein has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows a comparable redox-active potential, and it (50 μM, 4 h) can activate Nrf2. Negletein shows significant antimicrobial activity. Negletein has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.Negletein has anti- Alzheimer's disease activity, it inhibits the iron-dependent formation of ROS and also blocks the iron-induced oligomerization of amyloid beta 42 in vitro. Negletein (IC50: 3.89 +/- 0.39 microM) exhibits potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor.

Key Properties

• CAS Number: 29550-13-8
• MW: 284.26
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₂O₅
• SMILES: COC1=C(C(=C2C(=C1)OC(=CC2=O)C3=CC=CC=C3)O)O
• Target: Others
• Solubility: In Vitro: DMSO : 100 mg/mL (351.79 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Negletein

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