Nedometinib

SKU: orb2278796

Description

Nedometinib (NFX-179) is a selective MEK1 inhibitor that suppresses the MAPK pathway, demonstrating dose-dependent inhibition of human squamous cell carcinoma growth in vitro. Its research applications include studying oncogenic signaling in skin malignancies and evaluating antitumor efficacy in preclinical models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2252314-46-6
• MW: 470.24
• Purity: 99.18% (May vary between batches)
• Formula: C₁₇H₁₆FIN₄O₃
• SMILES: O=C(NOCCO)C=1C=2C=CC=NC2N(C1NC3=CC=C(I)C=C3F)C
• Target: p38 MAPK,PERK,MEK
• Solubility: DMSO:80 mg/mL (170.13 mM)

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MEK1, NFX 179, NFX179, NFX-179

Compound Identifiers

PubChem CID

146585168