NECA

SKU: orb1220445

Description

NECA is an agonist of Adenosine receptor increases cerebral extravasation of fluorescein and low molecular weight dextran independent of blood-brain barrier modulation.

Key Properties

• CAS Number: 35920-39-9
• MW: 308.29
• Purity: >98% (HPLC)
• Formula: C₁₂H₁₆N₆O₄
• SMILES: CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
• Target: AChR
• Solubility: DMSO:150 mg/mL (486.55 mM)

Bioactivity

• In Vivo:
  After the administration of 5'-N-Ethylcarboxamidoadenosine (NECA), the mean number of cocaine infusions obtained per session is decreased significantly in a dose-dependent manner [5'-N-Ethylcarboxamidoadenosine (NECA): F(4, 12) = 14.9; P<0.001]. The administration of 5'-N-Ethylcarboxamidoadenosine (NECA) [F(4, 12) = 16.1; P<0.001] results in a significant increase in latencies above values obtained for vehicle treatment. Daily i.p. injection of 5'-N-Ethylcarboxamidoadenosine (NECA) at 0.3 mg/kg/day for two weeks reduces malondialdehyde (MDA) levels in diabetic rats, but does not affect control rats. Daily treatment with NECA (0.3 mg/kg/day, i.p. for two weeks) reduces diabetes-induced gene expression of tumor necrosis factor (TNF)-α and interleukin (IL)-18 in diabetic rats, but does not affect control rats. Daily i.p. injection of 5'-N-Ethylcarboxamidoadenosine (NECA) at 0.3 mg/kg/day for two weeks also blocks the activation of JNK MAPK in diabetic rats, but does not affect control rats.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5'-N-Ethylcarboxamidoadenosine

Quick Database Links

Gene Symbol

AChR