Neboglamine hydrochloride

SKU: orb1689415

Description

Neboglamine hydrochloride (CR-2249 hydrochloride) is an orally bioavailable positive allosteric modulator of NMDA receptors. It exhibits neuroprotective and cognitive-enhancing properties, making it a candidate for research in psychiatric disorders like schizophrenia and autoimmune conditions such as lupus erythematosus. Studies utilize it in both in vitro receptor assays and in vivo behavioral models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2759182-59-5
• MW: 292.8
• Purity: 99.19% (May vary between batches)
• Formula: C₁₃H₂₅ClN₂O₃
• SMILES: N(C([C@H](CCC(O)=O)N)=O)C1CCC(C)(C)CC1.Cl
• Target: NMDAR,iGluR

Bioactivity

• In Vivo:
  In male Wistar rats, Neboglamine hydrochloride (20 mg/kg; subcutaneous injection) increased neuronal activity in brain regions, specifically in the prefrontal cortex (PFCX) from 38.5 to 121.3, nucleus accumbens (NAc) from 14.5 to 69.1, and lateral septal nucleus (LSN) from 16.2 to 73.1, with no effect on the dorsolateral striatum (DL-STR).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CR-2249 hydrochloride, NMDA, XY 2401 hydrochloride

Compound Identifiers

PubChem CID

165412562