NDI-Lyso

SKU: orb2802036

Description

NDI-Lyso is a cathepsin B-activated prodrug that selectively targets cancer cell lysosomes. Upon enzyme-triggered self-assembly into nanofibers, it induces lysosomal membrane permeabilization and caspase-independent cell death, demonstrating potent activity against diverse cancer lines, including drug-resistant models, with low toxicity to normal cells. Its mechanism supports research in lysosome-targeted therapies and non-apoptotic cell death pathways.

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• Target: Caspase,Apoptosis
• CAS Number: 2999646-19-2
• MW: 1469.69
• Formula: C₇₁H₁₀₀N₂₂O₁₃
• SMILES: O=C1C=2C3=C4C(C(=O)N(CCCCCC)C(=O)C4=CC2)=CC=C3C(=O)N1CCC(N[C@H](C(N[C@@H](CC5=CC=CC=C5)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)CC6=CC=CC=C6)=O

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172638707