NCI677397

SKU: orb3135986

Description

NCI677397 is a USP24 inhibitor. It enhances lipid ROS, activates cholesterol and fatty acid biosynthesis, and degrades ABC transporters, GPX4, and DHFR through the autophagy pathway. This process reduces p-gp levels, ultimately leading to ferroptosis in drug-resistant cancer cells. NCI677397 is relevant for research in lung and brain cancers.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 907547-06-2
• MW: 457.63
• Formula: C₂₈H₃₁N₃OS
• SMILES: O=C(C=1C=CC=CC1)C2=CC=C3SC=4C=CC=CC4N(C3=C2)CCCCN5CCN(C)CC5
• Target: Autophagy,Glutathione Peroxidase,Ferroptosis,ROS,DUB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Autophagy,Glutathione Peroxidase,Ferroptosis,ROS,DUB