NCI 126224

SKU: orb1979970

Description

NCI 126224 is a selective TLR4 antagonist that potently inhibits LPS-induced nitric oxide (IC50 = 0.31 µM), NF-κB activity, and pro-inflammatory cytokine production in macrophages and microglial cells. It also shows activity against TLR2/6-mediated NO production, making it a useful research tool for studying innate immunity and inflammation in vitro.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 65974-52-9
• MW: 265.2
• Purity: 99.95% (May vary between batches)
• Formula: C₁₂H₁₁NO₆
• SMILES: COC(/C(C(OC)=O)=C/C1=C(C=CC=C1)[N+]([O-])=O)=O
• Target: TLR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

277385