NCGC00378430

SKU: orb1298284

Description

NCGC00378430 is a small molecule inhibitor that potently disrupts the SIX1/EYA2 protein-protein interaction. This disruption impedes epithelial-mesenchymal transition (EMT) and metastatic progression, making it a valuable chemical probe for studying developmental biology, cancer metastasis, and tumor invasion in both cellular and animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 920650-00-6
• MW: 441.5
• Purity: 99.98% (May vary between batches)
• Formula: C₂₂H₂₃N₃O₅S
• SMILES: COc1ccc(NC(=O)c2cccc(c2)-n2cccc2)cc1S(=O)(=O)N1CCOCC1
• Target: Phosphatase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.47 mM);DMSO:90 mg/mL (203.85 mM)

Bioactivity

• In Vivo:
  NCGC00378430 was well tolerated when delivered to mice and significantly suppressed breast cancer associated metastasis in vivo without significantly altering primary tumor growth.
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• In Vitro:
  NCGC00378430 reduces the SIX1/EYA2 interaction. 8430 partially reversed transcriptional and metabolic profiles mediated by SIX1 overexpression and reversed SIX1-induced TGFβ signaling and EMT.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

p-Smad3, T47D, SIX1, SIX1-EYA2, Phosphatase, TGF-β, transcriptional, inhibit, Inhibitor, NCGC00378430, NCGC-00378430, NCGC 00378430, EYA2, FN1, EMT, E-CAD, MCF7, cancer, breast

Compound Identifiers

PubChem CID

16361161