NCGC00229600

SKU: orb1309349

Description

NCGC00229600 is a small molecule allosteric inverse agonist of the thyrotropin receptor (TSHR). It effectively blocks receptor activation induced by both TSH and stimulating autoantibodies, making it a valuable research tool for investigating Graves' disease pathogenesis and potential therapeutics in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1338824-20-6
• MW: 479.57
• Purity: 99.31% (May vary between batches)
• Formula: C₃₀H₂₉N₃O₃
• SMILES: COc1ccc(cc1COc1c(C)cccc1C)C1Nc2ccccc2C(=O)N1Cc1cccnc1
• Target: TSH Receptor
• Solubility: DMSO:40 mg/mL (83.41 mM);10% DMSO+90% Corn Oil:2 mg/mL (4.17 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Graves, fibroblasts, endogenously, Inhibitor, inhibit, NCGC 00229600, NCGC00229600, NCGC-00229600, disease, antibody, cAMP, Thyroid-stimulating hormone Receptor, Thyrotropin receptor, thyrotropin receptor (TSHR), TSHReceptor, TSH Receptor

Compound Identifiers

PubChem CID

50897816